Amy Schumer Wants to 'Get Down, if You Know What I Mean' Since Taking Hormones for Perimenopause: 'I'm Talking About Sex'

Amy Schumer is getting real about her health.

In a candid video posted to Instagram on March 21, the actress and comedian, 43, opened up about undergoing hormone replacement therapy for perimenopause as well as using weight-loss medication.

Schumer said she tried telehealth company Midi Health for her perimenopause symptoms. (She later invested in the company.) "They put me on estrogen and progesterone because I realized I was in perimenopause," Schumer shared. "And my symptoms from being perimenopause have disappeared."

Also known as menopausal transition, perimenopause is the transitional period before menopause when levels of estrogen start to decrease, according to the Cleveland Clinic. It often causes menopause-like symptoms, such as hot flashes or irregular periods, and can last for years.

Receiving estrogen and progesterone (hormone replacement therapy) helped Schumer with some of those symptoms.

"My hair is fuller, my skin is better," she continued. "I have more energy, I wanna get down more, you know what I mean ... I'm talking about sex."

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She also opened up about being on Mounjaro, after a negative experience a few years earlier with a similar GLP-1 medication. Now, she says, she is having a much better response. It's not covered by insurance, however — with the exception of treating diabetes or obesity, "which most of the internet thinks I have," she quipped.